2022 ACC/Big Ten Challenge results, schedule, predictions: UNC travels to Indiana, Duke hosts Ohio State

The final night of the ACC/Big Ten Challenge is on deck and brings a mouthwatering slate of games on Wednesday, highlighted by No. 25 Ohio State’s trip to No. 17 Duke and No. 18 North Carolina’s trip to No. 10 Indiana. This marks the final year of the challenge as the ACC goes in a new direction to play the SEC in a non-conference series beginning next season.

After two days, the ACC leads 5-3 with six games remaining in what could be an unforgettable final night, especially at Indiana and Duke. In both cases, Wednesday night marks the first away game against a prominent opponent this season. As such, the environment should be noisy for games that carry high stakes. North Carolina is riding a two-game losing streak at IU, and Duke is coming off a 19-point loss to Purdue.

Speaking of No. 6 Boilermakers, they will enter Florida State as heavy favorites against a Seminoles team trying to climb out of a 1-7 hole. In other action, Miami hosts Rutgers, Notre Dame hosts No. 20 Michigan State and Nebraska hosts Boston College. Each game represents a chance to build momentum before league play begins.

Here are the expert picks for Wednesday’s action from the CBS Sports team as we say goodbye to the ACC/Big Ten Challenge.

Monday’s ACC/Big Ten Challenge results

Virginia Tech 65, Minnesota 57 – Summary
Pitt 87, Northwestern 58 — Summary

Tuesday’s ACC/Big Ten Challenge results

Clemson 101, Penn State 94 (2OT) — GameTracker
No. 22 Maryland 79, Louisville 54 — GameTracker
No. 16 Illinois 73, Syracuse 44 — GameTracker
Wake Forest 78, Wisconsin 75 — GameTracker
Iowa 81, Georgia Tech 65 – GameTracker
No. 3 Virginia 70, Michigan 68 — GameTracker

ACC leads 5-3

Wednesday’s ACC/Big Ten Challenge schedule

No. 25 Ohio State at No. 17 Duke

19:15 | ESPN and fuboTV (Try Free)

Featured game | Duke Blue Devils vs. Ohio State Buckeyes

In four games away from indoor Cameron Stadium, Duke is shooting an abysmal 18.8 percent from 3-point range. In four games at home, he’s shooting 37.4 percent from 3-point range. In their two losses – both away from home – the Blue Devils were a combined 5 of 40 from deep. Home court advantage is huge for Duke here, and the Blue Devils should shoot decently enough from the outside to cover against an Ohio State team that can struggle with Duke’s length up front. Pick: Duke -5.5

No. 5 Purdue at Florida State

19:15 | ESPN2 and fuboTV (Try Free)

Featured game | Florida State Seminoles vs. Purdue Boilermakers

These have been two of the most surprising teams in the nation so far this season for different reasons. Purdue is 6-0 with wins over Gonzaga and Duke after losing stars Jaden Ivey and Trevion Williams from last season’s team. Florida State is 1-7 and on track for a historically bad season. Things should improve for the Seminoles eventually, but it’s hard to see that happening here. Purdue can cover this huge spread because one of its greatest strengths is rebounding, which is one of Florida State’s main weaknesses. Pick: Purdue -14.5

Rutgers in Miami

19:15 | ESPNU and fuboTV (Try Free)

Rutgers center Cliff Omorui will be a matchup problem for the undersized Hurricanes. The 6-11 junior is averaging 16.8 points and 10 rebounds per game, and the Scarlet Knights have excelled defensively — albeit mostly against huge opponents — thanks in large part to his defense. Miami is still figuring out its identity and committed about 15 turnovers in a narrow win at UCF on Sunday. Pick: Rutgers +3

No. 18 North Carolina at No. 10 Indiana

21:15 | ESPN and fuboTV (Try Free)

Featured game | Indiana Hoosiers vs. North Carolina Tar Heels

After playing Morehead State, Bethune-Cookman, Little Rock and Jackson State at home, the Hoosiers finally have an opponent coming to the Assembly Hall. The place will be in an absolute frenzy to see Indiana’s most hyped team in the last few seasons take on another blue blood. North Carolina has shown its flaws in full early this season and still isn’t good enough defensively to handle a dynamic Indiana team in this environment. Pick: Indiana -6.5

No. 20 Michigan State at Notre Dame

21:15 | ESPN2 and fuboTV (Try Free)

Featured game | Notre Dame Fighting Irish vs. Michigan State Spartans

Michigan State has struggled to force turnovers so far this season, and Notre Dame is among the least turnover-prone teams in the nation. The Fighting Irish will take care of the basketball at home and get plenty of 3-point shots. Their only loss thus far came in their only game away from home, and that was because they made just 2 of 17 3-point shots. Play this game anywhere else and the Spartans are the pick. But at home, Notre Dame can cover and possibly win. Pick: Notre Dame +1.5

Boston College in Nebraska

21:15 | ESPNU and fuboTV (Try Free)

Featured game | Nebraska Cornhuskers vs. Boston College Eagles

Boston College allows just 62.1 points per game, making the Eagles a strong defensive team that is unlikely to be blown out by a Nebraska team that plays at a relatively slow pace. BC is one of the nation’s worst 3-point shooting teams so far this season, but has nowhere to go but up from averaging just 4.1 3-pointers made per game. It’s not like one bad shooting night spells doom for the Eagles. They hit a combined 4 of 27 looks from deep against Wyoming and Road in their last two games and won both. Choice: Boston College +6

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