(This is an excerpt from the Health Counds information bulletin, which we present the latest medical studies on Tuesdays and Thursdays.)
Submitted by Nancy Lapid
(Reuters) -Researchers changed A kidney blood type to blood type kidneys and successfully transplanted it, they reported natural biomedical engineering -avans, which could reduce the time of waiting for new organs and save lives.
And the type of patients who make up more than half of the kidney waiting lists can only get from donors with blood -type blood, but the kidneys are often given to others because they are universally compatible. As a result, patients O Type usually waits two or four years longer, and many wait, and the researchers said in their report.
Traditional blood type incompatibility methods require intensive treatment days to suppress the recipient’s immune system, and special enzymes are used for the new method to replace the organ rather than the patient.
In the first human experiment, the kidney converted kidney was transplanted to a dead recipient of the brain. For two days, the kidney acted without the signs of a rapid immune reaction, which can destroy an incompatible organ within minutes.
On the third day, the investigators saw a mild reaction, but the damage was much less serious than in the typical blood type, and there were signs that the body began to tolerate the organ, the report said.
“This is the first time we have seen this performance in the human model,” said Dr. Stephen Withers from the University of British Colombia, who was the leader of the enzyme. “It gives us an invaluable understanding of how to improve long -term results.”
Researchers said other obstacles were confirmation of clinical trials.
Experimental gene therapy deals with diabetic kidney disease
Experimental gene therapy, proven in mice, can one day help protect against kidney disease caused by type 1 diabetes, researchers report.
“Kidney disease is a serious and life-changing complication of diabetes, which can progress quietly over the years,” said dr. Faye Riley, a research communication leading Diabetes UK, which helped to finance the investigation, the report said.
Previous studies have shown that a protein called Vegf-C helps maintain blood vessel health in glomeruli, tiny kidney filters that remove waste and toxins from the blood.
In laboratory experiments, researchers used a harmless virus to present the human vegf-C gene to human kidney cells in test tubes and mouse kidney cells with type 1 diabetes.
The test tube cells developed a functional Vegf-C, and researchers reported molecular therapy.
Not only did the kidneys work better after treatment, but it seemed that glomeruli were protected from lesions, investigators found.
“There is definitely new treatments to prevent kidney damage to people with diabetes, and this new approach is first examined by the main cause,” Riley said.
Treatment led to a 64% decreased protein called albumin in the urine, which is a common sign of kidney disease. Decrease is more than twice what the American Diabetes Association recommends to slow down the progression of chronic kidney disease.
“This promising study can lead to a whole new way to protect the kidneys in diabetes and prevent devastating renal failure,” Riley said.
Fluid restriction often in children often too high
Most US children undergoing surgery are much longer than needed without fluids, researchers reported a meeting of the American Society of Anesthesiologists in San Antonio, Texas.
Based on ASA guidelines, healthy babies and children can safely drink clear fluids such as water and fruit juice without pulp, up to two hours before anesthesia.
Reviewing nearly 72,000 patients under 18 years of age in US hospitals from 2016 to 2024. Inactive surgery was performed and investigators found that more than 80% of clear fluids were denied at least twice as long as needed.
The average time of time all children were fasting from clear fluids from 2016 to 2024, from 11 hours to 9 hours. But for babies who 2016 6.7 hours, and 6.3 hours 2024.
It is recommended that children in two hours before the procedure to reduce the risk of fluid in the lungs, which can lead to choking or pneumonia.
However, fasting from transparent fluids for a longer period of time can be uncomfortable and increase thirst, anxiety, pain, nausea and vomiting, according to Dr. Alexander Nagrebetsky from Boston General Hospital in Boston.
“It can also be harmful,” said Nagrebetsky. “Children and babies are particularly vulnerable to dehydration and calorie loss, which can increase stress and slowly recover from surgery.”
He added that surgery teams should encourage patients to drink water and sugar fluids up to two hours before the procedure.
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(Nancy Lapid Report; Edit Bill Berkrot)