When surveyed a supercostalist over 110, they are inevitably asked to share their tips on longevity.
And what if their secret could be scientifically explored? What can their genome tell about aging and why do they avoid diseases that require so many other people? If the secrets were revealed, perhaps they might help others to live as long?
Such issues are a recent document published on Wednesday, Journal Cell Reports Medicine, which studied Maria Brany Morera, a US -born Spanish woman who died in 2024. August, at the age of 117 and 168, the genome, shortly after becoming the oldest person in the world.
“She was a very generous personality trying to help, so it was great to work with her,” CNN told Dr. Manel Esteller, Joseep Carreras Leukemia Research Institute in Barcelona, Barcelona, Spain.
Branyas, shown with Esteller – Manel Esteller
Estherler and the research team before examining her genome and comparing it to 75 other women in Iberia, before studying the group, took examples of Banyas blood, saliva, urine and feces.
In general, they concluded that Bryny lived for so long because both won a genetic lottery and lived a healthy lifestyle. She both had genes that protected from normal age -related diseases and followed a healthy lifestyle and diet.
“She was happy from the beginning and got an extra plus in her life,” said Esteller, attributing about half of Bryn, a longevity to his genetics and about half of her lifestyle.
“She never smoked, never drunk alcohol, loved to work as long as she could (not) … She lived in the countryside, she did a moderated exercise (usually walking an hour a day) … She had a diet containing olive oil, Mediterranean style and, yogurt,” she said CNN.
If Bryny’s lifestyle was a bit unusual, it may be her yogurt consumption as she ate three servings a day.
Researchers raised the hypothesis that, along with the rest of the diet, this habit maintained the intestinal microbiome, reminiscent of a much younger person and reduced the level of inflammation.
Maria Branyas, shown in 1925
Still, Brany love for yogurt did not necessarily have caused her “joint fitness”, and her intestinal microbiome “probably reflects that she is actually very good for all those microbes because of all other factors that are good in her body,” said Claire Steves, a professor of aging London, who did not participate in the study.
In addition to eating a lot of yogurt, Bryny had a variety of gene variants that helped her healthy. Some of those found by the research team were a gene associated with immune function and cognitive abstinence, a gene that affects how effective the body metabolize fat, and other gene associated with aging brain health and heart disease.
“The level of completeness in this work is extraordinary,” Steves told CNN.
“They were very deep and were able to appreciate many different biological aging mechanisms …, My note, this is the first document that is actually done in this detail,” she said, adding that future research should see whether the conclusions are repeated with other superceived.
Steves, like the researchers themselves, warned not to draw broad conclusions in this study, which focuses on only one person, because the aging process is different for everyone.
“When you only look at one person, you can’t be sure if what you see is because only Fluke can’t be sure that the relationship is clear,” Steves said, though she added that attention can still offer some insights.
For example, after researching the Banyas genome, the research team was able to show that “especially advanced age and poor health are not essentially related,” as they said in their study.
“Inappropriate health age is inevitable. This is due to biological mechanisms … This is something we can change,” Steves said, adding that the document shows: “It will not be one bullet, it must be several different paths.”
Esteller hopes that researchers will be able to refer to the development of medicines that can refer to these specific elements by identifying healthy aging genes and proteins.
“Our goal should not be to live up to 117,” Steves added. “What we want to do is try to get confused when we are not worried and suffering from as little as possible. And that’s exactly what this lady seems to have done for a long time.”
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