The study focused on evaluating the effects of heat-killed TWK10 on exercise capacity, muscle strength, physiological adaptation and body composition in untrained but healthy volunteers.
Physical performance, handgrip strength, muscle weight and endurance time, which are related to exercise performance, were found to be significantly improved by administering TWK10 for six weeks at one-tenth the dose used in previous studies.
Conducted as a placebo-controlled, double-blind clinical trial, the study included 30 healthy adult men aged 20 to 40 with no professional exercise training.
Before the trial, participants underwent measurements for height, weight, biochemical parameters and exercise endurance capacity. Fifteen participants were randomized to the control group, while the remaining participants were part of the TWK10-HK groups.
After the two-week washout period, the control group received two placebos, while the TWK10-HK group took two TWK10-HK capsules daily after meals for six weeks.
The dose of TWK10-HK administered in this study was 30 billion cells per day, one-tenth of the amount used in previous studies.
Assessment included assessments of exercise endurance in a 30-min exercise challenge, grip strength, fatigue-related parameters, and body composition. Dietary information was also recorded both before and after administration and before the exercise endurance test.
To analyze the impact of heat-killed TWK10 administration on subjects’ physical performance, the study used principal component analysis (PCA). All 30 subjects were evaluated before and after administration based on seven physical characteristics: body weight (BW), body mass index (BMI), muscle weight, body fat mass, grip strength (right and left hand), and time to endurance.
